09 Apr 2019 02:40
Background Merkel cell carcinoma (MCC) is a rare, aggressive malignancy, with high rates of recurrence and metastasis.
Objective To evaluate predictors of sentinel lymph node (SLN) positivity in Merkel cell carcinoma using the National Cancer Database (NCDB).
Methods The NCDB, from 2012-2014, was used to identify 3,048 patients with MCC of which 1,174 received a SLN biopsy (SLNB). Predictors of SLN positivity were evaluated using logistic regression, overall survival (OS) was evaluated using a Cox proportional hazards model.
Results Of patients who underwent SLNB, those with primary lesions on the trunk (OR 1.98, 95%CI 1.23-3.17, p=0.004), tumor infiltrating lymphocytes (OR 1.58, 95%CI 1.01-2.46, p=0.04), or lymphovascular invasion (OR 3.45, 95%CI 2.51-4.76, p<0.001) were more likely to have positive SLN on multivariate analysis. OS was negatively affected by age ≥75 (HR 2.55, 95%CI 1.36-4.77, p=0.003), male gender (HR 1.78, 95%CI 1.09-2.91, p=0.022), immunosuppression (3.51, 95%CI 1.72-7.13, p=0.001), and SLN positivity (3.15, 95%CI 1.98-5.04, p<0.001).
Limitations Lack of disease specific survival, potential selection bias from a retrospective dataset.
Conclusions Truncal MCC, tumor infiltrating lymphocytes and presence of lymphovascular invasion were independent predictors of positive SLN. OS was negatively affected by advancing age, male gender, immunosuppression, and SLN positivity.
|Fonte||Journal of the American Academy of Dermatology|
|Titolo originale||Sentinel lymph node biopsy in Merkel cell carcinoma: Predictors of sentinel lymph node positivity and association with overall survival|
|Autori||Rosalynn RZ. Conic, Jennifer Ko, Stephanie Saridakis, t al|
|Link fonte||Link articolo originale|
|Argomenti correlati|| linfonodo sentinella carcinoma basocellulare |
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