Real-world effectiveness and tolerability of dupilumab in adult atopic dermatitis


11 Nov 2020 01:25 Bacheca


Abstract

Dupilumab (Dupixent®) is the first biologic drug licensed for treatment of adults with atopic dermatitis (AD). Data regarding its long‐term real‐world effectiveness and tolerability are limited.

We report comprehensive outcome data at one year for the first 100 adult patients initiated on dupilumab in a specialist eczema clinic (May 2017‐November 2019). In this prospective, observational cohort study (HRA UK ref.268527) all patients received dupilumab at licenced dose. Wherever possible, patients on other systemic treatment(s) underwent 4‐week washout prior to dupilumab. All patients were given preservative‐free lubricating eye ointment prior to dupilumab in view of ophthalmic complications reported in trials1‐3. Disease activity and patient‐reported outcome measures were assessed at baseline, week 12, week 24 and 1 year of treatment. Adverse events (AE) were recorded and classified4.

Inserito da segreteria SIDeMaST

Ti è piaciuto questo contenuto?

Approfondimenti

FonteWiley Online Library
Titolo originaleReal‐world effectiveness and tolerability of dupilumab in adult atopic dermatitis: A single centre, prospective one‐year observational cohort study of the first 100 patients treated
AutoriA.V. Sears, R.T. Woolf, E. Gribaleva, W. Abdelrahman, S. Robbie, B. Menon, B. Kirkham, C.H. Smith, A.E. Pink
Link fonteLink articolo originale
Argomenti correlati dermatite atopica Dupilumab

SIDeMaST è su Facebook

Segui la pagina e diffondi la cultura dermatologica condividendo i contenuti.