Isothiazolinone derivatives and allergic contact dermatitis: a review and update


20 Feb 2019 01:47 Ricerca


Allergic contact dermatitis (ACD) from isothiazolinones has frequently been described in the literature. Following an epidemic of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in the 1980s, and more recently to MI, the Scientific Committee on Consumer Safety of the European Commission banned their use in leave‐on products, while restricting that in rinse‐off cosmetics.

Despite a decreasing prevalence of ACD from MCI/MI and MI, cases caused by occupational exposure and non‐cosmetic isothiazolinone sources are on the rise. Moreover, sensitization to newer and lesser known isothiazolinones has been reported.

This paper reviews the epidemiology of contact allergy to different isothiazolinones, clinical presentation of isothiazolinone‐induced ACD, most relevant sensitization sources and potential cross‐reactions between isothiazolinone derivatives. It also provides an update on recent legislative measures.

J Eur Acad Dermatol Venereol. 2019 Feb;33(2):267-276.

Inserito da segreteria SIDeMaST

Approfondimenti

FonteJournal of the European Academy of Dermatology and Venereology
Titolo originaleIsothiazolinone derivatives and allergic contact dermatitis: a review and update
AutoriHerman A, Aerts O, de Montjoye L, Tromme I, Goossens A, Baeck M.
Link fonteLink articolo originale
Argomenti correlati dermatite da contatto

SIDeMaST è su Facebook

Segui la pagina e diffondi la cultura dermatologica condividendo i contenuti.

Ti è piaciuto questo contenuto?