Rassegna letteratura
Dermatologia25 ott 2004
Prevalenza della ipersensibilità da contatto nei pazienti con ulcera della gamba
Study aims: (1) To determine the prevalence of allergen sensitivity in patients with past or present leg ulcers in 2 North American study centers vs European study findings and the North American Contact Dermatitis Group (NACDG) database and (2) to delineate a standard battery of allergens for patch testing in North American patients that is representative of the newer dressings and wound care products
07 ott 2004
Il pimecrolimus topico nel lupus eritematoso cutaneo
Topical treatment of cutaneous lupus erythematosus usually includes potent glucocorticosteroids. However, prolonged use causes adverse side effects including skin atrophy as the foremost concern. In contrast to glucocorticosteroids, the anti-inflammatory and immunosuppressive macrolactam pimecrolimus has no atrophogenic potential
07 ott 2004
Tacrolimus topico e laser ad eccimeri nella terapia della vitiligine
Aim of the study is to compare the efficacy of combined tacrolimus and 308-nm excimer laser therapy vs 308-nm excimer laser monotherapy in treating vitiligo
22 set 2004
Una terapia efficace e duratura delle acromie del piebaldismo
Objective is to induce permanent repigmentation of large achromic lesions in patients suffering from piebaldism by means of autologous cultured epidermal grafts using a rapid, simple and non-invasive surgical procedure
22 set 2004
L'importanza dei sintomi nei pazienti affetti da psoriasi
The main dermatology textbooks describe only in passing pruritus in psoriasis and rarely mention other symptoms. A quantification of the presence of symptoms is not available for clinical subgroups of psoriasis. The study aims to investigate the prevalence of symptoms experienced by patients with different clinical types of psoriasis
09 set 2004
Una ampia meta-analisi sull'impiego di antifungini sistemici nell'onicomicosi
A cumulative meta-analysis of the randomized controlled trials (RCTs) for antimycotic agents was performed to determine whether the pooled estimate of the cure rates has remained consistent over the years. Furthermore, for each agent we compared the overall meta-analytical average of both mycological and clinical response rates of RCTs vs. open studies
09 set 2004
Meccanismo d'azione della fotochemioterapia extracorporea nella GvHD cronica
Chronic graft-versus-host disease (GvHD) affects 50% of long-term bone marrow transplant survivors and remains a cause of major long-term morbidity in these patients despite aggressive therapy. Extracorporeal photochemotherapy (ECP), considered as an effective treatment for patients with erythrodermic cutaneous T-cell lymphoma (CTCL), has recently been used successfully in the treatment of GvHD
26 ago 2004
Pazienti con alopecia androgenetica che assumono finasteride non hanno alterazioni dell'attività sessuale
Study to evaluate variations in sexual and erectile function in subjects taking 1 mg of finasteride for androgenetic alopecia by administering the abridged 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire before and during treatment
26 ago 2004
Confermata inefficacia della supplementazione dietetica di acidi grassi essenziali nella dermatite atopica
Essential fatty acids are components of cell membranes and precursors of immunomodulating factors that may play a role in the inflammatory and immunological pathogenesis of atopic dermatitis. Trials of supplementation with essential fatty acids (EFA) to alleviate atopic dermatitis (AD) have given inconsistent results
01 ago 2004
Leflunomide: una nuova possibilità terapeutica nelle forme severe di dermatite atopica
Based on the increasing knowledge of T-cell-mediated pathogenesis in atopic dermatitis (AD), systemic immunosuppressive drugs are increasingly applied. The chronic, relapsing course of severe AD necessitates a drug, both efficacious and safe in long-term application. Leflunomide is a pyrimidine de novo synthesis-inhibiting immunosuppressant exhibiting an extremely long in vivo half life of its active metabolite
01 ago 2004
Il tazarotene topico nella terapia del basalioma
The study aims to investigate the efficacy of tazarotene in a large series of BCCs, better to define the clinical advantages and the mechanisms of action in vivo
14 lug 2004
Generazione di precursori di cellule neuronali da cellule dermiche di individui adulti
Neural stem cells are a potential source of cells for drug screening or cell-based treatments for neurodegenerative diseases. However, ethical and practical considerations limit the availability of neural stem cells derived from human embryonic tissue. An alternative source of human neural stem cells is needed; a source that is readily accessible, easily expanded, and reliably induced to a neural fate
14 lug 2004
Onicomicosi bianca superficiale
The study analyze the epidemiology, responsible agents, clinical features, and outcome of white superficial onychomycosis (WSO)
29 giu 2004
Le caratteristiche cliniche e dermoscopiche del melanoma amelanotico
Amelanotic malignant melanoma is a subtype of cutaneous melanoma with little or no pigment on visual inspection. It may mimic benign and malignant variants of both melanocytic and nonmelanocytic lesions. The study aims to evaluate whether dermoscopy is also a useful technique for the diagnosis of amelanotic/hypomelanotic melanoma (AHM)
29 giu 2004
Gli esteri dell'acido fumarico nella terapia della psoriasi: un'esperienza italiana
The study aims to evaluate the efficacy and safety of fumaric acid esters, in particular dimethylfumarate (DMF), in the treatment of moderate to severe plaque psoriasis intolerant and/or resistant to other conventional systemic therapies
16 giu 2004
La pentossifillina orale è più efficace dei corticosteroidi topici nella Sindrome di Schamberg
Oral pentoxifylline vs topical betamethasone in Schamberg disease: a comparative randomized investigator-blinded parallel-group trial
16 giu 2004
Una revisione sulla patogenesi della micosi fungoide
A review of the pathogenesis of mycosis fungoides. Department of Dermatology, Yale University School of Medicine, New Haven, Conn, USA
03 giu 2004
Follow up clinico dei pazienti con melanoma stadio I/II sottoposti a linfonodo sentinella
The aim was to analyse the parameters associated with a higher risk of occult nodal metastases, to evaluate the clinical outcome of melanoma patients who underwent SLN procedure, and to identify by means of multivariate analysis the prognostic parameters with independent predictive value on disease-free survival (DFS) in node-positive and negative patients
03 giu 2004
Riproducibilità dei patch test con Dermatofagoides nei pazienti con dermatite atopica
The aim of the study was to evaluate the reproducibility of APTs with house dust mites by simultaneously patch testing AD patients
14 mag 2004
Sindrome di Sjogren: una revisione del gruppo italiano di immunodermatologia
Various cutaneous manifestations have been described (xerosis, eyelid dermatitis, angular cheilitis, cutaneous vasculitis and annular erythema) in Sjögren's syndrome (SS), but so far only three studies on large numbers of SS patients have been carried out. The frequency of cutaneous manifestations and their association with specific clinical or immunological parameters have never been studied. The aim of the Italian Group of Immunodermatology was to evaluate these associations in a large number of SS patients