Effectiveness of Low Doses of Hyaluronidase to Remove Hyaluronic Acid Filler Nodules

Importance

Although hyaluronidase is known to remove hyaluronic acid fillers, use of low doses has not been well studied.

Objective

To assess the effectiveness and dose-related effect of small quantities of hyaluronidase to treat hyaluronic acid filler nodules.

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Murad Alam, MD, MSCI, MBA; Rosemara Hughart, MD; Amelia Geisler, BS; Kapila Paghdal, MD; Amanda Maisel, BS; Alexandra Weil, BS; Dennis P. West, PhD; Emir Veledar, PhD; Emily Poon, PhD

JAMA Dermatol. Published online April 5, 08. doi:10.1001/jamadermatol.2018.0515